Post-translational Modifications of Integral Membrane Proteins Resolved by Top-down Fourier Transform Mass Spectrometry with Collisionally Activated Dissociation

Integral membrane proteins remain a challenge to proteomics because they contain domains with physicochemical properties poorly suited to today's bottom-up protocols. These transmembrane regions may potentially contain post-translational modifications of functional significance, and thus develo...

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Autori principali: Ryan, Christopher M., Souda, Puneet, Bassilian, Sara, Ujwal, Rachna, Zhang, Jun, Abramson, Jeff, Ping, Peipei, Durazo, Armando, Bowie, James U., Hasan, S. Saif, Baniulis, Danas, Cramer, William A., Faull, Kym F., Whitelegge, Julian P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2010
Soggetti:
PTM Methodology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871414/
https://ncbi.nlm.nih.gov/pubmed/20093275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900516-MCP200
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