An Oncolytic Adenovirus Enhanced for Toll-like Receptor 9 Stimulation Increases Antitumor Immune Responses and Tumor Clearance

Oncolytic viruses represent a multifaceted tool for cancer treatment. In addition to specific killing of cancer cells (oncolysis), these agents also provide danger signals prompting the immune system to stimulate an antitumor immune response. To increase adenovirus adjuvancy, we engineered the genom...

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Bibliografiska uppgifter
Huvudupphovsmän: Cerullo, Vincenzo, Diaconu, Iulia, Romano, Valentina, Hirvinen, Mari, Ugolini, Matteo, Escutenaire, Sophie, Holm, Sirkka-Liisa, Kipar, Anja, Kanerva, Anna, Hemminki, Akseli
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2012
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498796/
https://ncbi.nlm.nih.gov/pubmed/22828500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.137
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