An Oncolytic Adenovirus Enhanced for Toll-like Receptor 9 Stimulation Increases Antitumor Immune Responses and Tumor Clearance

Oncolytic viruses represent a multifaceted tool for cancer treatment. In addition to specific killing of cancer cells (oncolysis), these agents also provide danger signals prompting the immune system to stimulate an antitumor immune response. To increase adenovirus adjuvancy, we engineered the genom...

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Detalhes bibliográficos
Main Authors: Cerullo, Vincenzo, Diaconu, Iulia, Romano, Valentina, Hirvinen, Mari, Ugolini, Matteo, Escutenaire, Sophie, Holm, Sirkka-Liisa, Kipar, Anja, Kanerva, Anna, Hemminki, Akseli
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498796/
https://ncbi.nlm.nih.gov/pubmed/22828500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.137
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