PKCδ Deficiency Perturbs Bone Homeostasis by Selective Uncoupling of Cathepsin K Secretion and Ruffled Border Formation in Osteoclasts

Bone homeostasis requires stringent regulation of osteoclasts, which secrete proteolytic enzymes to degrade the bone matrix. Despite recent progress in understanding how bone resorption occurs, the mechanisms regulating osteoclast secretion, and in particular the trafficking route of cathepsin K ves...

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Detalhes bibliográficos
Main Authors: Cremasco, Viviana, Decker, Corinne E., Stumpo, Deborah, Blackshear, Perry J., Nakayama, Keiichi I., Nakayama, Keiko, Lupu, Traian S., Graham, Daniel B., Novack, Deborah V., Faccio, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498518/
https://ncbi.nlm.nih.gov/pubmed/22806935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1701
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