PKCδ Deficiency Perturbs Bone Homeostasis by Selective Uncoupling of Cathepsin K Secretion and Ruffled Border Formation in Osteoclasts

Bone homeostasis requires stringent regulation of osteoclasts, which secrete proteolytic enzymes to degrade the bone matrix. Despite recent progress in understanding how bone resorption occurs, the mechanisms regulating osteoclast secretion, and in particular the trafficking route of cathepsin K ves...

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Hauptverfasser: Cremasco, Viviana, Decker, Corinne E., Stumpo, Deborah, Blackshear, Perry J., Nakayama, Keiichi I., Nakayama, Keiko, Lupu, Traian S., Graham, Daniel B., Novack, Deborah V., Faccio, Roberta
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498518/
https://ncbi.nlm.nih.gov/pubmed/22806935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1701
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