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Aesculetin Inhibits Osteoclastic Bone Resorption through Blocking Ruffled Border Formation and Lysosomal Trafficking

For the optimal resorption of mineralized bone matrix, osteoclasts require the generation of the ruffled border and acidic resorption lacuna through lysosomal trafficking and exocytosis. Coumarin-type aesculetin is a naturally occurring compound with anti-inflammatory and antibacterial effects. Howe...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Na, Woojin, Lee, Eun-Jung, Kang, Min-Kyung, Kim, Yun-Ho, Kim, Dong Yeon, Oh, Hyeongjoo, Kim, Soo-Il, Oh, Su Yeon, Kang, Young-Hee
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696459/
https://ncbi.nlm.nih.gov/pubmed/33203061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228581
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