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Somatic Mutations of PIK3R1 Promote Gliomagenesis

The phosphoinositide 3-kinase (PI3K) pathway is targeted for frequent alteration in glioblastoma (GBM) and is one of the core GBM pathways defined by The Cancer Genome Atlas. Somatic mutations of PIK3R1 are observed in multiple tumor types, but the tumorigenic activity of these mutations has not bee...

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Bibliographische Detailangaben
Hauptverfasser: Quayle, Steven N., Lee, Jennifer Y., Cheung, Lydia W T., Ding, Li, Wiedemeyer, Ruprecht, Dewan, Robert W., Huang-Hobbs, Emmet, Zhuang, Li, Wilson, Richard K., Ligon, Keith L., Mills, Gordon B., Cantley, Lewis C., Chin, Lynda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498106/
https://ncbi.nlm.nih.gov/pubmed/23166678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049466
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