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Separating the effects of internal friction and transition state energy to explain the slow, frustrated folding of spectrin domains
The elongated three-helix bundle domains spectrin R16 and R17 fold some two to three orders of magnitude more slowly than their homologue R15. We have shown that this slow folding is due, at least in part, to roughness in the free-energy landscape of R16 and R17. We have proposed that this roughness...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3497808/ https://ncbi.nlm.nih.gov/pubmed/22711800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201793109 |
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