Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4(+) and CD8(+) T cells

Naïve T cells continually recirculate between blood and secondary lymphoid organs, scanning dendritic cells (DC) for foreign antigen. Despite its importance for understanding how adaptive immune responses are efficiently initiated from rare precursors, a detailed quantitative analysis of this fundam...

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Bibliographic Details
Main Authors: Mandl, Judith N., Liou, Rachel, Klauschen, Frederick, Vrisekoop, Nienke, Monteiro, João P., Yates, Andrew J., Huang, Alex Y., Germain, Ronald N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497782/
https://ncbi.nlm.nih.gov/pubmed/23071319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211717109
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