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Thymic Positive Selection and the Mature T Cell Repertoire for Antigen Revisited
To support effective host defense, the T cell repertoire must balance breadth of recognition with sensitivity for antigen. The concept that T lymphocytes are positively selected in the thymus is established, but this achieves such a repertoire has not been resolved. Here we suggest that it is direct...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4152861/ https://ncbi.nlm.nih.gov/pubmed/25148022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.07.007 |
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