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Thymic Positive Selection and the Mature T Cell Repertoire for Antigen Revisited

To support effective host defense, the T cell repertoire must balance breadth of recognition with sensitivity for antigen. The concept that T lymphocytes are positively selected in the thymus is established, but this achieves such a repertoire has not been resolved. Here we suggest that it is direct...

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Autori principali: Vrisekoop, Nienke, Monteiro, João P., Mandl, Judith N., Germain, Ronald N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152861/
https://ncbi.nlm.nih.gov/pubmed/25148022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.07.007
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