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Neutralizing the function of a β-globin–associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain

Gene expression is primarily regulated by cis-regulatory DNA elements and trans-interacting proteins. Transcription factors bind in a DNA sequence–specific manner and recruit activities that modulate the association and activity of transcription complexes at specific genes. Often, transcription fact...

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Detalhes bibliográficos
Main Authors: Barrow, Joeva J., Masannat, Jude, Bungert, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497758/
https://ncbi.nlm.nih.gov/pubmed/23074246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207677109
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