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Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca(2+) events, and IK(Ca) channels, reducing arteriolar tone
Endothelial cell (EC) Ca(2+)-activated K channels (SK(Ca) and IK(Ca) channels) generate hyperpolarization that passes to the adjacent smooth muscle cells causing vasodilation. IK(Ca) channels focused within EC projections toward the smooth muscle cells are activated by spontaneous Ca(2+) events (Ca(...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3497745/ https://ncbi.nlm.nih.gov/pubmed/23071308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211946109 |
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