Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca(2+) events, and IK(Ca) channels, reducing arteriolar tone

Endothelial cell (EC) Ca(2+)-activated K channels (SK(Ca) and IK(Ca) channels) generate hyperpolarization that passes to the adjacent smooth muscle cells causing vasodilation. IK(Ca) channels focused within EC projections toward the smooth muscle cells are activated by spontaneous Ca(2+) events (Ca(...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bagher, Pooneh, Beleznai, Timea, Kansui, Yasuo, Mitchell, Ray, Garland, Christopher J., Dora, Kim A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497745/
https://ncbi.nlm.nih.gov/pubmed/23071308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211946109
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