Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca(2+) events, and IK(Ca) channels, reducing arteriolar tone

Endothelial cell (EC) Ca(2+)-activated K channels (SK(Ca) and IK(Ca) channels) generate hyperpolarization that passes to the adjacent smooth muscle cells causing vasodilation. IK(Ca) channels focused within EC projections toward the smooth muscle cells are activated by spontaneous Ca(2+) events (Ca(...

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Detalles Bibliográficos
Main Authors: Bagher, Pooneh, Beleznai, Timea, Kansui, Yasuo, Mitchell, Ray, Garland, Christopher J., Dora, Kim A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497745/
https://ncbi.nlm.nih.gov/pubmed/23071308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211946109
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