Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope

The strongest genetic influence on immune control in HIV-1 infection is the HLA class I genotype. Rapid disease progression in B-clade infection has been linked to HLA-B*35 expression, in particular to the less common HLA-B*3502 and HLA-B*3503 subtypes but also to the most prevalent subtype, HLA-B*3...

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Auteurs principaux: Matthews, Philippa C., Koyanagi, Madoka, Kløverpris, Henrik N., Harndahl, Mikkel, Stryhn, Anette, Akahoshi, Tomohiro, Gatanaga, Hiroyuki, Oka, Shinichi, Juarez Molina, Claudia, Valenzuela Ponce, Humberto, Avila Rios, Santiago, Cole, David, Carlson, Jonathan, Payne, Rebecca P., Ogwu, Anthony, Bere, Alfred, Ndung'u, Thumbi, Gounder, Kamini, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Shapiro, Roger, Brander, Christian, Walker, Bruce, Sewell, Andrew K., Reyes Teran, Gustavo, Heckerman, David, Hunter, Eric, Buus, Søren, Takiguchi, Masafumi, Goulder, Philip J. R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497693/
https://ncbi.nlm.nih.gov/pubmed/22973023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01381-12
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