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IκB Kinase ε Phosphorylates TRAF2 To Promote Mammary Epithelial Cell Transformation

NF-κB transcription factors are central regulators of inflammation and when dysregulated contribute to malignant transformation. IκB kinase ε (IKKε; IKKi, encoded by IKBKE) is a breast oncogene that is amplified in 30% of breast cancers and drives transformation in an NF-κB-dependent manner. Here we...

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Detalhes bibliográficos
Main Authors: Shen, Rhine R., Zhou, Alicia Y., Kim, Eejung, Lim, Elgene, Habelhah, Hasem, Hahn, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497603/
https://ncbi.nlm.nih.gov/pubmed/23007157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00468-12
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