The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

The deletion of phenylalanine 1486 (F1486del) in the human cardiac voltage-gated sodium channel (hNav1.5) is associated with fatal long QT (LQT) syndrome. In this study we determined how F1486del impairs the functional properties of hNav1.5 and alters action potential firing in heterologous expressi...

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Detalhes bibliográficos
Main Authors: Song, Weihua, Xiao, Yucheng, Chen, Hanying, Ashpole, Nicole M, Piekarz, Andrew D, Ma, Peilin, Hudmon, Andy, Cummins, Theodore R, Shou, Weinian
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497567/
https://ncbi.nlm.nih.gov/pubmed/22826127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.235374
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