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IFNγR signaling mediates alloreactive T-cell trafficking and GVHD
The clinical goal of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is to minimize GVHD while maintaining GvL. Here, we show that interferon γ receptor-deficient (IFNγR(−/−)) allogeneic Tconv, which possess normal alloreactivity and cytotoxicity, induce significantly less GVHD than w...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3496960/ https://ncbi.nlm.nih.gov/pubmed/22972985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-403196 |
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