IFNγR signaling mediates alloreactive T-cell trafficking and GVHD

The clinical goal of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is to minimize GVHD while maintaining GvL. Here, we show that interferon γ receptor-deficient (IFNγR(−/−)) allogeneic Tconv, which possess normal alloreactivity and cytotoxicity, induce significantly less GVHD than w...

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Bibliographic Details
Main Authors: Choi, Jaebok, Ziga, Edward D., Ritchey, Julie, Collins, Lynne, Prior, Julie L., Cooper, Matthew L., Piwnica-Worms, David, DiPersio, John F.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496960/
https://ncbi.nlm.nih.gov/pubmed/22972985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-403196
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