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Mechanism of platelet dense granule biogenesis: study of cargo transport and function of Rab32 and Rab38 in a model system

Dense granules are important in platelet aggregation to form a hemostatic plug as evidenced by the increased bleeding time in mice and humans with dense granule deficiency. Dense granules also are targeted by antiplatelet agents because of their role in thrombus formation. Therefore, the molecular u...

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Bibliografische gegevens
Hoofdauteurs: Ambrosio, Andrea L., Boyle, Judith A., Di Pietro, Santiago M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496959/
https://ncbi.nlm.nih.gov/pubmed/22927249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-420745
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