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Scaleable processes for the synthesis of (−)-β-D-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (−)-β-D-2-aminopurine dioxolane (APD)

An efficient and scalable synthesis of (−)-DAPD and (−)-APD has been developed. We discovered that t-butyl cyanoacetate can be used as a new additive for the sugar nucleoside base coupling step en route to DAPD with improved β-selectivity and an isolated yield four fold greater than the original pro...

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Bibliografske podrobnosti
Main Authors: Zhou, Longhu, Coats, Steven J., Zhang, Hongwang, Junxing, Shi, Bobeck, Drew R., Schinazi, Raymond F.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496293/
https://ncbi.nlm.nih.gov/pubmed/23162170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2012.05.039
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