Synthesis and anti-HIV activity of (-)-β-D-(2R,4R) 1,3-dioxolane 2,6-diamino purine (DAPD) (Amdoxovir) and (-)-β-D-(2R,4R) 1,3-dioxolane guanosine (DXG) prodrugs

Prodrugs of (-)-β-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD), organic salts of DAPD, 5′-l-valyl DAPD and N-1 substituted (-)-β-D-(2R,4R)-1,3-dioxolane guanosine (DXG) have been synthesized with the objective of finding molecules which might be superior to DAPD and DXG in solubility as well as...

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Main Authors: Narayanasamy, Janarthanan, Pullagurla, Manik R., Sharon, Ashoke, Wang, Jianing, Schinazi, Raymond F., Chu, Chung K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2025703/
https://ncbi.nlm.nih.gov/pubmed/17532483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2007.03.005
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