The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation

INTRODUCTION: Although a high frequency of androgen receptor (AR) expression in human breast cancers has been described, exploiting this knowledge for therapy has been challenging. This is in part because androgens can either inhibit or stimulate cell proliferation in pre-clinical models of breast c...

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Autori principali: Garay, Joseph P, Karakas, Bedri, Abukhdeir, Abde M, Cosgrove, David P, Gustin, John P, Higgins, Michaela J, Konishi, Hiroyuki, Konishi, Yuko, Lauring, Josh, Mohseni, Morassa, Wang, Grace M, Jelovac, Danijela, Weeraratna, Ashani, Sherman Baust, Cheryl A, Morin, Patrice J, Toubaji, Antoun, Meeker, Alan, De Marzo, Angelo M, Lewis, Gloria, Subhawong, Andrea, Argani, Pedram, Park, Ben H
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496145/
https://ncbi.nlm.nih.gov/pubmed/22321971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3112
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