Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells

INTRODUCTION: The taxanes paclitaxel and docetaxel are widely used in the treatment of breast, ovarian, and other cancers. Although their cytotoxicity has been attributed to cell-cycle arrest through stabilization of microtubules, the mechanisms by which tumor cells die remains unclear. Paclitaxel h...

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Detalhes bibliográficos
Main Authors: Sprowl, Jason A, Reed, Kerry, Armstrong, Stephen R, Lanner, Carita, Guo, Baoqing, Kalatskaya, Irina, Stein, Lincoln, Hembruff, Stacey L, Tam, Adam, Parissenti, Amadeo M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496117/
https://ncbi.nlm.nih.gov/pubmed/22225778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3083
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