Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance

BACKGROUND: Anthracyclines and taxanes are commonly used in the treatment of breast cancer. However, tumor resistance to these drugs often develops, possibly due to overexpression of drug transporters. It remains unclear whether drug resistance in vitro occurs at clinically relevant doses of chemoth...

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Detalhes bibliográficos
Principais autores: Hembruff, Stacey L, Laberge, Monique L, Villeneuve, David J, Guo, Baoqing, Veitch, Zachary, Cecchetto, Melanie, Parissenti, Amadeo M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596802/
https://ncbi.nlm.nih.gov/pubmed/18980695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-318
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