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Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance

BACKGROUND: Anthracyclines and taxanes are commonly used in the treatment of breast cancer. However, tumor resistance to these drugs often develops, possibly due to overexpression of drug transporters. It remains unclear whether drug resistance in vitro occurs at clinically relevant doses of chemoth...

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Autori principali: Hembruff, Stacey L, Laberge, Monique L, Villeneuve, David J, Guo, Baoqing, Veitch, Zachary, Cecchetto, Melanie, Parissenti, Amadeo M
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596802/
https://ncbi.nlm.nih.gov/pubmed/18980695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-318
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