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PROTON-COUPLED DYNAMICS IN LACTOSE PERMEASE

Lactose permease of Escherichia coli (LacY) catalyzes symport of a galactopyranoside and an H(+) via an alternating access mechanism. The transition from an inward- to an outward-facing conformation of LacY involves sugar-release followed by deprotonation. Because the transition depends intimately u...

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Bibliografiske detaljer
Main Authors: Andersson, Magnus, Bondar, Ana-Nicoleta, Freites, J. Alfredo, Tobias, Douglas J., Kaback, H. Ronald, White, Stephen H.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496080/
https://ncbi.nlm.nih.gov/pubmed/23000385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.021
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