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Lactose Permease and the Alternating Access Mechanism
Crystal structures of the lactose permease of Escherichia coli (LacY) reveal twelve, mostly irregular transmembrane α-helices surrounding a large cavity open to the cytoplasm and a tightly sealed periplasmic side (inward-facing conformation). However, LacY is highly dynamic, and binding of a galacto...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210931/ https://ncbi.nlm.nih.gov/pubmed/21995338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2014294 |
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