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Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding
The lactose permease (LacY) catalyzes galactoside/H(+) symport via an alternating access mechanism in which sugar- and H(+)-binding sites in the middle of the molecule are alternatively exposed to either side of the membrane by opening and closing of inward- and outward-facing cavities. The crystal...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174601/ https://ncbi.nlm.nih.gov/pubmed/21896727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112157108 |
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