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Structures of dNTP Intermediate States During DNA Polymerase Active Site Assembly
DNA polymerase and substrate conformational changes are essential for high fidelity DNA synthesis. Structures of DNA polymerase (pol) β in complex with DNA show the enzyme in an ‘open’ conformation. Subsequent to binding the nucleotide, the polymerase ‘closes’ around the nascent base pair with two m...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3496073/ https://ncbi.nlm.nih.gov/pubmed/22959623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.008 |
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