Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment

Impaired DNA damage response pathways may create vulnerabilities of cancer cells that can be exploited therapeutically. One such selective vulnerability is the sensitivity of BRCA1- or BRCA2-defective tumors (hence defective in DNA repair by homologous recombination, HR) to inhibitors of the poly(AD...

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Main Authors: Oplustilova, Lenka, Wolanin, Kamila, Mistrik, Martin, Korinkova, Gabriela, Simkova, Dana, Bouchal, Jan, Lenobel, Rene, Bartkova, Jirina, Lau, Alan, O’Connor, Mark J., Lukas, Jiri, Bartek, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495826/
https://ncbi.nlm.nih.gov/pubmed/22983061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22026
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