Aberrations of the MRE11–RAD50–NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer‐predisposing gene

The MRE11, RAD50, and NBS1 genes encode proteins of the MRE11–RAD50–NBS1 (MRN) complex critical for proper maintenance of genomic integrity and tumour suppression; however, the extent and impact of their cancer‐predisposing defects, and potential clinical value remain to be determined. Here, we repo...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Bartkova, Jirina, Tommiska, Johanna, Oplustilova, Lenka, Aaltonen, Kirsimari, Tamminen, Anitta, Heikkinen, Tuomas, Mistrik, Martin, Aittomäki, Kristiina, Blomqvist, Carl, Heikkilä, Päivi, Lukas, Jiri, Nevanlinna, Heli, Bartek, Jiri
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2008
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Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527773/
https://ncbi.nlm.nih.gov/pubmed/19383352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2008.09.007
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