TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human cancer remain unclear. Here, through an unbiased small interfering RNA screen, we identified and validated TOPBP1 as a novel determinant whose...

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Udgivet i:J Cell Biol
Main Authors: Moudry, Pavel, Watanabe, Kenji, Wolanin, Kamila M., Bartkova, Jirina, Wassing, Isabel E., Watanabe, Sugiko, Strauss, Robert, Troelsgaard Pedersen, Rune, Oestergaard, Vibe H., Lisby, Michael, Andújar-Sánchez, Miguel, Maya-Mendoza, Apolinar, Esashi, Fumiko, Lukas, Jiri, Bartek, Jiri
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2016
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748576/
https://ncbi.nlm.nih.gov/pubmed/26811421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201507042
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