TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Pedersen, Rune Troelsgaard, Kruse, Thomas, Nilsson, Jakob, Oestergaard, Vibe H., Lisby, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539992/
https://ncbi.nlm.nih.gov/pubmed/26283799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502107
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados