Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin.

Two analogs of porcine insulin with substitutions of leucine for phenylalanine in the COOH-terminal region of the insulin B chain have been prepared by a combination of solid-phase synthesis and semisynthesis. Solid-phase synthesis of the substituted octapeptides B23-B30 bearing the trifluoracetyl g...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Tager, H, Thomas, N, Assoian, R, Rubenstein, A, Saekow, M, Olefsky, J, Kaiser, E T
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1980
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349578/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6997872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.6.3181
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