Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin.
Two analogs of porcine insulin with substitutions of leucine for phenylalanine in the COOH-terminal region of the insulin B chain have been prepared by a combination of solid-phase synthesis and semisynthesis. Solid-phase synthesis of the substituted octapeptides B23-B30 bearing the trifluoracetyl g...
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| Опубліковано в:: | Proc Natl Acad Sci U S A |
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| Автори: | , , , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
National Academy of Sciences
1980
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349578/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6997872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.6.3181 |
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