Development and validation of a PCR-based assay for the selection of patients more likely to benefit from therapeutic treatment with alkylating drugs

AIM: In order to develop and validate a simple, sensitive and rapid method for the quantitation of alkylating drug-induced DNA damage. METHODS: HepG2 cells and blood samples were treated with alkylating drugs (melphalan, cisplatin, carboplatin). Gene-specific damage was examined using Southern blot...

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Bibliographische Detailangaben
Hauptverfasser: Stefanou, Dimitra T, Episkopou, Hara, Kyrtopoulos, Soterios A, Bamias, Aristotelis, Gkotzamanidou, Maria, Bamia, Christina, Liakou, Christina, Bekyrou, Margarita, Sfikakis, Petros P, Dimopoulos, Meletios-Athanasios, Souliotis, Vassilis L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2012
Schlagworte:
Pharmacogenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495149/
https://ncbi.nlm.nih.gov/pubmed/22432918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04274.x
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