Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response

CD8+ T cells are central to the eradication of intracellular pathogens, but they can also act to limit inflammation and immunopathology. During primary respiratory viral infection CD8+ effector T cells release the immunosuppressive cytokine IL-10, which is essential for host survival. Here we report...

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Autori principali: Perona-Wright, Georgia, Kohlmeier, Jacob E., Bassity, Elizabeth, Freitas, Tori C., Mohrs, Katja, Cookenham, Tres, Situ, Haozhong, Pearce, Edward J., Woodland, David L., Mohrs, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494933/
https://ncbi.nlm.nih.gov/pubmed/23091017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119133109
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