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Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response
CD8+ T cells are central to the eradication of intracellular pathogens, but they can also act to limit inflammation and immunopathology. During primary respiratory viral infection CD8+ effector T cells release the immunosuppressive cytokine IL-10, which is essential for host survival. Here we report...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494933/ https://ncbi.nlm.nih.gov/pubmed/23091017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119133109 |
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