T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy

T cell-mediated allergy to Ni(++) is one of the most common forms of allergic contact dermatitis, but how the T-cell receptor (TCR) recognizes Ni(++) is unknown. We studied a TCR from an allergic patient that recognizes Ni(++) bound to the MHCII molecule DR52c containing an unknown self-peptide. We...

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Bibliographic Details
Main Authors: Yin, Lei, Crawford, Frances, Marrack, Philippa, Kappler, John W., Dai, Shaodong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494899/
https://ncbi.nlm.nih.gov/pubmed/23091041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215928109
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