Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome

BACKGROUND: Using mRNA expression-derived signatures as predictors of individual patient outcome has been a goal ever since the introduction of microarrays. Here, we addressed whether analyses of tumour mRNA at the exon level can improve on the predictive power and classification accuracy of gene-ba...

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Bibliographic Details
Main Authors: Schramm, A, Schowe, B, Fielitz, K, Heilmann, M, Martin, M, Marschall, T, Köster, J, Vandesompele, J, Vermeulen, J, de Preter, K, Koster, J, Versteeg, R, Noguera, R, Speleman, F, Rahmann, S, Eggert, A, Morik, K, Schulte, J H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Genetics and Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494449/
https://ncbi.nlm.nih.gov/pubmed/23047593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.391
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