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A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

Neuroblastoma, a childhood cancer that originates from neural crest-derived cells, is the most common deadly solid tumor of infancy. Amplification of the MYCN oncogene, which occurs in approximately 20–25% of human neuroblastomas, is the most prominent genetic marker of high-stage disease. The avail...

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Τόπος έκδοσης:	Oncogene
Κύριοι συγγραφείς:	Althoff, K, Beckers, A, Bell, E, Nortmeyer, M, Thor, T, Sprüssel, A, Lindner, S, De Preter, K, Florin, A, Heukamp, L C, Klein-Hitpass, L, Astrahantseff, K, Kumps, C, Speleman, F, Eggert, A, Westermann, F, Schramm, A, Schulte, J H
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Publishing Group 2015
Θέματα:	Original Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4487199/ https://ncbi.nlm.nih.gov/pubmed/25174395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.269
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A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

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