Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours

BACKGROUND: Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS: The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clonogenic survival assays. Expression of DNA rep...

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Detalhes bibliográficos
Main Authors: von Bueren, A O, Bacolod, M D, Hagel, C, Heinimann, K, Fedier, A, Kordes, U, Pietsch, T, Koster, J, Grotzer, M A, Friedman, H S, Marra, G, Kool, M, Rutkowski, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494444/
https://ncbi.nlm.nih.gov/pubmed/22976800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.403
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