Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2

Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis in species ranging from Drosophila to mammals. The Hh signal is transduced by Smoothened (Smo), a seven-transmembrane protein related to G protein coupled receptors. Despite a conserved mechanism by whi...

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Bibliographic Details
Main Authors: Yang, Cuiping, Chen, Wenlin, Chen, Yongbin, Jiang, Jin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494391/
https://ncbi.nlm.nih.gov/pubmed/22986504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.134
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