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Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops

The function and regulation of MDM2 as a component of a p53-dependent negative feedback loop has formed a core paradigm in the p53 field. This concept, now 20 years old, has been solidified by fields of protein science, transgenic technology, and drug discovery in human cancer. However, it has been...

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書誌詳細
主要な著者: Ponnuswamy, Anand, Hupp, Ted, Fåhraeus, Robin
フォーマット: Artigo
言語:Inglês
出版事項: SAGE Publications 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494372/
https://ncbi.nlm.nih.gov/pubmed/23150762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912454140
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