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Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops
The function and regulation of MDM2 as a component of a p53-dependent negative feedback loop has formed a core paradigm in the p53 field. This concept, now 20 years old, has been solidified by fields of protein science, transgenic technology, and drug discovery in human cancer. However, it has been...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
SAGE Publications
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494372/ https://ncbi.nlm.nih.gov/pubmed/23150762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912454140 |
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