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Scission of the p53-MDM2 Loop by Ribosomal Proteins
The oncoprotein MDM2 is both the transcriptional target and the predominant antagonist of the tumor suppressor p53. MDM2 inhibits the functions of p53 via a negative feedback loop that can be circumvented by several ribosomal proteins in response to nucleolar or ribosomal stress. Stress conditions i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494370/ https://ncbi.nlm.nih.gov/pubmed/23150763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912455200 |
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