Sub-Zero Temperature Chromatography for Reduced Back-Exchange and Improved Dynamic Range in Amide Hydrogen Deuterium Exchange Mass Spectrometry

Amide hydrogen/deuterium exchange is a commonly used technique for studying the dynamics of proteins and their interactions with other proteins or ligands. When coupled with liquid chromatography and mass spectrometry, hydrogen/deuterium exchange provides several unique advantages over other structu...

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Bibliografiske detaljer
Main Authors: Venable, John D., Okach, Linda, Agarwalla, Sanjay, Brock, Ansgar
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494095/
https://ncbi.nlm.nih.gov/pubmed/23025328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac302488h
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