SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis

Loss of SPRY2 and activation of receptor tyrosine kinases are common events in prostate cancer (PC). However, the molecular basis of their interaction and clinical impact remains to be fully examined. SPRY2 loss may functionally synergize with aberrant cellular signalling to drive PC and to promote...

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Detalhes bibliográficos
Main Authors: Gao, Meiling, Patel, Rachana, Ahmad, Imran, Fleming, Janis, Edwards, Joanne, McCracken, Stuart, Sahadevan, Kanagasabai, Seywright, Morag, Norman, Jim, Sansom, Owen, Leung, Hing Y
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494076/
https://ncbi.nlm.nih.gov/pubmed/22649008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100944
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