SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis

Loss of SPRY2 and activation of receptor tyrosine kinases are common events in prostate cancer (PC). However, the molecular basis of their interaction and clinical impact remains to be fully examined. SPRY2 loss may functionally synergize with aberrant cellular signalling to drive PC and to promote...

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Autors principals: Gao, Meiling, Patel, Rachana, Ahmad, Imran, Fleming, Janis, Edwards, Joanne, McCracken, Stuart, Sahadevan, Kanagasabai, Seywright, Morag, Norman, Jim, Sansom, Owen, Leung, Hing Y
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2012
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Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494076/
https://ncbi.nlm.nih.gov/pubmed/22649008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100944
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