Tyrosine Phosphorylation of the p21 Cyclin-dependent Kinase Inhibitor Facilitates the Development of Proneural Glioma

Phosphorylation of Tyr-88/Tyr-89 in the 3(10) helix of p27 reduces its cyclin-dependent kinase (CDK) inhibitory activity. This modification does not affect the interaction of p27 with cyclin-CDK complexes but does interfere with van der Waals and hydrogen bond contacts between p27 and amino acids in...

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Bibliographic Details
Main Authors: Hukkelhoven, Ellen, Liu, Yuhui, Yeh, Nancy, Ciznadija, Daniel, Blain, Stacy W., Koff, Andrew
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493897/
https://ncbi.nlm.nih.gov/pubmed/23007395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366542
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