The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity

Mutation of the TRIM (tripartite motif)-NHL family members brat and mei-P26 perturb the differentiation of transit-amplifying progenitor cells resulting in tumour-like phenotypes. The NHL (named after the NCL1, HT2A and LIN41 repeat) domain is essential for their growth suppressive activity, and the...

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Bibliographic Details
Published in:Biochem J
Main Authors: Raheja, Radhika, Liu, Yuhui, Hukkelhoven, Ellen, Yeh, Nancy, Koff, Andrew
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404499/
https://ncbi.nlm.nih.gov/pubmed/24393003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131288
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